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Interleukin-1 receptor (IL-1R) mediates epilepsy-induced sleep disruption

Overview of attention for article published in BMC Neuroscience, November 2016
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Title
Interleukin-1 receptor (IL-1R) mediates epilepsy-induced sleep disruption
Published in
BMC Neuroscience, November 2016
DOI 10.1186/s12868-016-0309-0
Pubmed ID
Authors

Tzu-Rung Huang, Shuo-Bin Jou, Yu-Ju Chou, Pei-Lu Yi, Chun-Jen Chen, Fang-Chia Chang

Abstract

Sleep disruptions are common in epilepsy patients. Our previous study demonstrates that homeostatic factors and circadian rhythm may mediate epilepsy-induced sleep disturbances when epilepsy occurs at different zeitgeber hours. The proinflammatory cytokine, interleukin-1 (IL-1), is a somnogenic cytokine and may also be involved in epileptogenesis; however, few studies emphasize the effect of IL-1 in epilepsy-induced sleep disruption. We herein hypothesized that IL-1 receptor type 1 (IL-1R1) mediates the pathogenesis of epilepsy and epilepsy-induced sleep disturbances. We determined the role of IL-1R1 by using IL-1R1 knockout (IL-1R1 -/- KO) mice. Our results elucidated the decrease of non-rapid eye movement (NREM) sleep during the light period in IL-1R -/- mice and confirmed the somnogenic role of IL-1R1. Rapid electrical amygdala kindling was performed to induce epilepsy at the particular zeitgeber time (ZT) point, ZT13. Our results demonstrated that seizure thresholds induced by kindling stimuli, such as the after-discharge threshold and successful kindling rates, were not altered in IL-1R -/- mice when compared to those obtained from the wildtype mice (IL-1R +/+ mice). This result suggests that IL-1R1 is not involved in kindling-induced epileptogenesis. During sleep, ZT13 kindling stimulation significantly enhanced NREM sleep during the subsequent 6 h (ZT13-18) in wildtype mice, and sleep returned to the baseline the following day. However, the kindling-induced sleep alteration was absent in the IL-1R -/- KO mice. These results indicate that the IL-1 signal mediates epilepsy-induced sleep disturbance, but dose not participate in kindling-induced epileptogenesis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 26%
Student > Bachelor 5 13%
Professor 2 5%
Student > Doctoral Student 2 5%
Student > Ph. D. Student 2 5%
Other 7 18%
Unknown 10 26%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Neuroscience 4 11%
Agricultural and Biological Sciences 3 8%
Engineering 3 8%
Nursing and Health Professions 2 5%
Other 5 13%
Unknown 12 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2017.
All research outputs
#18,483,671
of 22,903,988 outputs
Outputs from BMC Neuroscience
#883
of 1,247 outputs
Outputs of similar age
#303,040
of 415,136 outputs
Outputs of similar age from BMC Neuroscience
#19
of 31 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,247 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.