Title |
Ki-67 labeling in canine perianal glands neoplasms: a novel approach for immunohistological diagnostic and prognostic
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Published in |
BMC Veterinary Research, April 2013
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DOI | 10.1186/1746-6148-9-83 |
Pubmed ID | |
Authors |
Rodrigo Storti Pereira, Augusto Schweigert, Guilherme Dias de Melo, Fernando Vissani Fernandes, Felipe Augusto Ruiz Sueiro, Gisele Fabrino Machado |
Abstract |
The antibody Ki-67 is a reliable and easy tool to accurately assess the growth fraction of neoplasms in humans and animals, and it has been used to predict the clinical outcome. Therefore, the aim of the present study was to investigate the immunohistochemical expression pattern of Ki-67 in normal and neoplastic perianal glands of dogs to evaluate the possible use of this proliferation marker as an ancillary method of perianal tumor diagnosis. We studied 42 cases of perianal gland neoplasms including adenomas (n = 15), epitheliomas (n = 15), and carcinomas (n = 12). As controls, 13 tissue samples from normal perianal glands were used. A Ki-67 index was established by a computer-assisted image analysis and compared with manual counting. |
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Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 68 | 97% |
Demographic breakdown
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Student > Postgraduate | 13 | 19% |
Other | 9 | 13% |
Student > Master | 8 | 11% |
Researcher | 6 | 9% |
Student > Doctoral Student | 5 | 7% |
Other | 15 | 21% |
Unknown | 14 | 20% |
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Immunology and Microbiology | 1 | 1% |
Other | 1 | 1% |
Unknown | 15 | 21% |