↓ Skip to main content

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

Overview of attention for article published in BMC Cancer, April 2013
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
25 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells
Published in
BMC Cancer, April 2013
DOI 10.1186/1471-2407-13-198
Pubmed ID
Authors

Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy, Fuyuhiko Tamanoi

Abstract

Lung cancer is the leading cause of cancer-related mortality. Therapies against non-small cell lung cancer (NSCLC) are particularly needed, as this type of cancer is relatively insensitive to chemotherapy and radiation therapy. We recently identified GGTI compounds that are designed to block geranylgeranylation and membrane association of signaling proteins including the Rho family G-proteins. One of the GGTIs is P61A6 which inhibits proliferation of human cancer cells, causes cell cycle effects with G1 accumulation and exhibits tumor-suppressing effects with human pancreatic cancer xenografts. In this paper, we investigated effects of P61A6 on non-small cell lung cancer (NSCLC) cells in vitro and in vivo.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 24%
Student > Doctoral Student 2 8%
Professor 2 8%
Student > Postgraduate 2 8%
Student > Master 1 4%
Other 3 12%
Unknown 9 36%
Readers by discipline Count As %
Medicine and Dentistry 5 20%
Agricultural and Biological Sciences 4 16%
Chemistry 3 12%
Biochemistry, Genetics and Molecular Biology 2 8%
Nursing and Health Professions 1 4%
Other 1 4%
Unknown 9 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2013.
All research outputs
#6,327,743
of 12,372,945 outputs
Outputs from BMC Cancer
#1,326
of 4,558 outputs
Outputs of similar age
#56,099
of 144,345 outputs
Outputs of similar age from BMC Cancer
#5
of 12 outputs
Altmetric has tracked 12,372,945 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,558 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 144,345 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.