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Keratinocytes at the uppermost layer of epidermis might act as sensors of atmospheric pressure change

Overview of attention for article published in Extreme Physiology & Medicine, October 2016
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Citations

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Title
Keratinocytes at the uppermost layer of epidermis might act as sensors of atmospheric pressure change
Published in
Extreme Physiology & Medicine, October 2016
DOI 10.1186/s13728-016-0052-2
Pubmed ID
Authors

Mitsuhiro Denda

Abstract

It has long been suggested that climate, especially atmospheric pressure change, can cause health problems ranging from migraine to myocardial infarction. Here, I hypothesize that the sensory system of epidermal keratinocytes mediates the influence of atmospheric pressure change on the human physiological condition. We previously demonstrated that even subtle changes of atmospheric pressure (5-20 hPa) induce elevation of intracellular calcium level in cultured human keratinocytes (excitation of keratinocytes). It is also established that communication occurs between epidermal keratinocytes and peripheral nerve systems. Moreover, various neurotransmitters and hormones that influence multiple systems (nervous, cardiovascular, endocrine, and immune systems) are generated and released from epidermal keratinocytes in response to various external stimuli. Thus, I suggest that pathophysiological phenomena induced by atmospheric pressure changes might be triggered by epidermal keratinocytes.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 31%
Researcher 3 23%
Student > Master 2 15%
Other 2 15%
Professor 1 8%
Other 1 8%
Readers by discipline Count As %
Medicine and Dentistry 3 23%
Biochemistry, Genetics and Molecular Biology 2 15%
Agricultural and Biological Sciences 2 15%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Immunology and Microbiology 1 8%
Other 1 8%
Unknown 3 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2016.
All research outputs
#7,522,094
of 8,674,965 outputs
Outputs from Extreme Physiology & Medicine
#91
of 94 outputs
Outputs of similar age
#240,625
of 297,831 outputs
Outputs of similar age from Extreme Physiology & Medicine
#3
of 3 outputs
Altmetric has tracked 8,674,965 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 94 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,831 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.