Title |
Development of a transmission model for dengue virus
|
---|---|
Published in |
Virology Journal, April 2013
|
DOI | 10.1186/1743-422x-10-127 |
Pubmed ID | |
Authors |
Rebecca C Christofferson, Michael K McCracken, Ann-Marie Johnson, Daniel M Chisenhall, Christopher N Mores |
Abstract |
Dengue virus (DENV) research has historically been hampered by the lack of a susceptible vertebrate transmission model. Recently, there has been progress towards such models using several varieties of knockout mice, particularly those deficient in type I and II interferon receptors. Based on the critical nature of the type I interferon response in limiting DENV infection establishment, we assessed the permissiveness of a mouse strain with a blunted type I interferon response via gene deficiencies in interferon regulatory factors 3 and 7 (IRF3/7 -/- -/-) with regards to DENV transmission success. We investigated the possibility of transmission to the mouse by needle and infectious mosquito, and subsequent transmission back to mosquito from an infected animal during its viremic period. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 89 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 25% |
Researcher | 21 | 23% |
Student > Master | 12 | 13% |
Other | 8 | 9% |
Lecturer | 7 | 8% |
Other | 13 | 14% |
Unknown | 9 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 29 | 31% |
Medicine and Dentistry | 16 | 17% |
Biochemistry, Genetics and Molecular Biology | 13 | 14% |
Environmental Science | 4 | 4% |
Veterinary Science and Veterinary Medicine | 3 | 3% |
Other | 14 | 15% |
Unknown | 14 | 15% |