Title |
Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors
|
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Published in |
BMC Medicine, April 2013
|
DOI | 10.1186/1741-7015-11-109 |
Pubmed ID | |
Authors |
Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz |
Abstract |
Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome characterized by the development of benign nerve-sheath tumors, which transform to malignant peripheral nerve-sheath tumors (MPNST) in about 8 to 13% of patients with NF1. MPNST are invasive sarcomas with extremely poor prognosis, and their development may correlate with internal tumor load of patients with NF1. Because early identification of patients with NF1 at risk for developing MPNST should improve their clinical outcome, the aim of this study was to identify serum biomarkers for tumor progression in NF1, and to analyze their correlation with tumor type and internal tumor load. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 50% |
Mexico | 1 | 25% |
United States | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 19% |
Student > Master | 7 | 13% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 6 | 11% |
Other | 4 | 8% |
Other | 14 | 26% |
Unknown | 6 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 36% |
Biochemistry, Genetics and Molecular Biology | 9 | 17% |
Agricultural and Biological Sciences | 8 | 15% |
Unspecified | 2 | 4% |
Immunology and Microbiology | 1 | 2% |
Other | 8 | 15% |
Unknown | 6 | 11% |