Title |
Conversion of pericytes to neurons: a new guest at the reprogramming convention
|
---|---|
Published in |
Stem Cell Research & Therapy, January 2013
|
DOI | 10.1186/scrt150 |
Pubmed ID | |
Authors |
Emmanuel Nivet, Ignacio Sancho-Martinez, Juan Carlos Izpisua Belmonte |
Abstract |
ABSTRACT: Reprogramming strategies allow for the generation of virtually any cell type of the human body, which could be useful for cell-based therapy. Among the different reprogramming technologies available, direct lineage conversion offers the possibility to change the phenotype of a cell type to another one without pushing cells backwards to a plastic/proliferative stage. This approach has raised the possibility to apply a similar process in vivo in order to compensate for functional cell loss. Historically, the cerebral tissue is a prime choice for developing cell-based treatments. As local pericyte accumulation is observed after central nervous system injury, it can be reasoned that this cell type might be a good candidate for the conversion into new neurons in vivo. In this article, and by focusing on recent observations from Karow and colleagues demonstrating the possibility to convert human brain-derived pericytes into functional neurons, we present a brief overview of the state of the art and attempt to offer perspective as to how these interesting laboratory findings could be translated in the clinic. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 35% |
Student > Doctoral Student | 3 | 13% |
Researcher | 3 | 13% |
Student > Bachelor | 2 | 9% |
Student > Master | 2 | 9% |
Other | 1 | 4% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Other | 1 | 4% |
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