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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints
|
|---|---|
| Published in |
Environmental Health, November 2016
|
| DOI | 10.1186/s12940-016-0199-8 |
| Pubmed ID | |
| Authors |
Christopher Leonetti, Craig M. Butt, Kate Hoffman, Stephanie C. Hammel, Marie Lynn Miranda, Heather M. Stapleton |
| Abstract |
Brominated flame retardants (BFRs) are endocrine disruptors that bioaccumulate in the placenta, but it remains unclear if they disrupt tissue thyroid hormone (TH) metabolism. Our primary goal was to investigate associations between placental BFRs, TH levels, Type 3 deiodinase (DIO3) activity and TH sulfotransferase (SULT) activities. Placenta samples collected from 95 women who delivered term (>37 weeks) infants in Durham, NC, USA (enrolled 2010-2011) were analyzed for polybrominated diphenyl ethers (PBDEs), 2,4,6-tribromophenol (2,4,6-TBP), THs (T4, T3 and rT3), and DIO3 and TH SULT activities. PBDEs and 2,4,6-TBP were detected in all placenta samples. PBDEs were higher in placental tissues from male infants compared to female infants, with 2,4,6-TBP and BDE-209 levels approximately twice as high. Among male infants, placental BDE-99 and BDE-209 were negatively associated with rT3 placental levels. For female infants, placental BDE-99 and 2,4,6-TBP were positively associated with T3 concentrations. DIO3 activity was also significantly higher in placental tissues from male infants compared to females, while 3,3'-T2 SULT activity was significantly higher in placental tissues from females compared to males. Among males, several PBDE congeners were positively correlated with T3 SULT, while BDE-99 was negatively associated with T3 SULT among females. Associations generally remained after adjustment for potential confounding by maternal age and gestational age at delivery. These results suggest BFRs accumulate in the placenta and potentially alter TH function in a sex-specific manner, a possible mechanism to explain the sex-dependent impacts of environmental exposure on children's growth and development. More research is needed to elucidate the effects of BFRs on placenta function during pregnancy, as well as the biological consequences of exposure and thyroid disruption. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 73 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 25% |
| Researcher | 13 | 18% |
| Professor > Associate Professor | 5 | 7% |
| Student > Master | 5 | 7% |
| Student > Bachelor | 4 | 5% |
| Other | 10 | 14% |
| Unknown | 18 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 12 | 16% |
| Agricultural and Biological Sciences | 9 | 12% |
| Medicine and Dentistry | 8 | 11% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Engineering | 4 | 5% |
| Other | 14 | 19% |
| Unknown | 20 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2020.
All research outputs
#7,247,852
of 22,903,988 outputs
Outputs from Environmental Health
#801
of 1,498 outputs
Outputs of similar age
#132,560
of 415,669 outputs
Outputs of similar age from Environmental Health
#12
of 29 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,498 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.3. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 415,669 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.