Title |
Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP)
|
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Published in |
BMC Pharmacology and Toxicology, April 2013
|
DOI | 10.1186/2050-6511-14-20 |
Pubmed ID | |
Authors |
H K Ruben Thanacoody, Alasdair Gray, James W Dear, Judy Coyle, Euan A Sandilands, David J Webb, Steff Lewis, Michael Eddleston, Simon HL Thomas, D Nicholas Bateman |
Abstract |
Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 40% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 68 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 10 | 14% |
Researcher | 7 | 10% |
Student > Postgraduate | 7 | 10% |
Student > Bachelor | 6 | 9% |
Student > Master | 5 | 7% |
Other | 17 | 24% |
Unknown | 18 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 51% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Agricultural and Biological Sciences | 2 | 3% |
Computer Science | 1 | 1% |
Other | 3 | 4% |
Unknown | 23 | 33% |