Title |
An optimized algorithm for detecting and annotating regional differential methylation
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Published in |
BMC Bioinformatics, April 2013
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DOI | 10.1186/1471-2105-14-s5-s10 |
Pubmed ID | |
Authors |
Sheng Li, Francine E Garrett-Bakelman, Altuna Akalin, Paul Zumbo, Ross Levine, Bik L To, Ian D Lewis, Anna L Brown, Richard J D'Andrea, Ari Melnick, Christopher E Mason |
Abstract |
DNA methylation profiling reveals important differentially methylated regions (DMRs) of the genome that are altered during development or that are perturbed by disease. To date, few programs exist for regional analysis of enriched or whole-genome bisulfate conversion sequencing data, even though such data are increasingly common. Here, we describe an open-source, optimized method for determining empirically based DMRs (eDMR) from high-throughput sequence data that is applicable to enriched whole-genome methylation profiling datasets, as well as other globally enriched epigenetic modification data. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
United Kingdom | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 50% |
Scientists | 3 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 10 | 6% |
Germany | 2 | 1% |
India | 1 | <1% |
Sweden | 1 | <1% |
Japan | 1 | <1% |
Russia | 1 | <1% |
Unknown | 144 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 45 | 28% |
Student > Ph. D. Student | 41 | 26% |
Student > Master | 13 | 8% |
Professor > Associate Professor | 11 | 7% |
Student > Bachelor | 8 | 5% |
Other | 27 | 17% |
Unknown | 15 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 70 | 44% |
Biochemistry, Genetics and Molecular Biology | 29 | 18% |
Computer Science | 13 | 8% |
Medicine and Dentistry | 8 | 5% |
Engineering | 5 | 3% |
Other | 16 | 10% |
Unknown | 19 | 12% |