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The Drosophila transcriptional network is structured by microbiota

Overview of attention for article published in BMC Genomics, November 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

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1 blog
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30 X users
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Citations

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47 Dimensions

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102 Mendeley
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Title
The Drosophila transcriptional network is structured by microbiota
Published in
BMC Genomics, November 2016
DOI 10.1186/s12864-016-3307-9
Pubmed ID
Authors

Adam J. Dobson, John M. Chaston, Angela E. Douglas

Abstract

Resident microorganisms (microbiota) have far-reaching effects on the biology of their animal hosts, with major consequences for the host's health and fitness. A full understanding of microbiota-dependent gene regulation requires analysis of the overall architecture of the host transcriptome, by identifying suites of genes that are expressed synchronously. In this study, we investigated the impact of the microbiota on gene coexpression in Drosophila. Our transcriptomic analysis, of 17 lines representative of the global genetic diversity of Drosophila, yielded a total of 11 transcriptional modules of co-expressed genes. For seven of these modules, the strength of the transcriptional network (defined as gene-gene coexpression) differed significantly between flies bearing a defined gut microbiota (gnotobiotic flies) and flies reared under microbiologically sterile conditions (axenic flies). Furthermore, gene coexpression was uniformly stronger in these microbiota-dependent modules than in both the microbiota-independent modules in gnotobiotic flies and all modules in axenic flies, indicating that the presence of the microbiota directs gene regulation in a subset of the transcriptome. The genes constituting the microbiota-dependent transcriptional modules include regulators of growth, metabolism and neurophysiology, previously implicated in mediating phenotypic effects of microbiota on Drosophila phenotype. Together these results provide the first evidence that the microbiota enhances the coexpression of specific and functionally-related genes relative to the animal's intrinsic baseline level of coexpression. Our system-wide analysis demonstrates that the presence of microbiota enhances gene coexpression, thereby structuring the transcriptional network in the animal host. This finding has potentially major implications for understanding of the mechanisms by which microbiota affect host health and fitness, and the ways in which hosts and their resident microbiota coevolve.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 3%
France 2 2%
Unknown 97 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 27%
Researcher 17 17%
Student > Master 13 13%
Student > Bachelor 5 5%
Professor 5 5%
Other 15 15%
Unknown 19 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 41%
Biochemistry, Genetics and Molecular Biology 19 19%
Immunology and Microbiology 8 8%
Environmental Science 4 4%
Computer Science 2 2%
Other 6 6%
Unknown 21 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2019.
All research outputs
#1,466,809
of 24,677,985 outputs
Outputs from BMC Genomics
#276
of 11,038 outputs
Outputs of similar age
#29,766
of 425,773 outputs
Outputs of similar age from BMC Genomics
#8
of 248 outputs
Altmetric has tracked 24,677,985 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,038 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,773 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 248 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.