Title |
Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial
|
---|---|
Published in |
Trials, March 2013
|
DOI | 10.1186/1745-6215-14-64 |
Pubmed ID | |
Authors |
Sarah R Kingsbury, Puvan Tharmanathan, Joy Adamson, Nigel K Arden, Fraser Birrell, Sarah Cockayne, John Dickson, Michael Doherty, Krysia S Dziedzic, Andrew Grainger, Catherine E Hewitt, Terence W O’Neill, David L Scott, Tonia L Vincent, Richard J Wakefield, Fiona E Watt, David J Torgerson, Philip G Conaghan |
Abstract |
Osteoarthritis (OA) is the most common type of arthritis, causing significant joint pain and disability. It is already a major cause of healthcare expenditure and its incidence will further increase with the ageing population. Current treatments for OA have major limitations and new analgesic treatments are needed. Synovitis is prevalent in OA and is associated with pain. Hydroxychloroquine is used in routine practice for treating synovitis in inflammatory arthritides, such as rheumatoid arthritis. We propose that treating patients with symptomatic hand OA with hydroxychloroquine will be a practical and safe treatment to reduce synovitis and pain. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Bulgaria | 1 | 17% |
Colombia | 1 | 17% |
Canada | 1 | 17% |
United States | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 3% |
Spain | 1 | <1% |
Unknown | 131 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 15% |
Student > Master | 14 | 10% |
Student > Bachelor | 13 | 10% |
Student > Postgraduate | 12 | 9% |
Other | 11 | 8% |
Other | 29 | 21% |
Unknown | 37 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 54 | 40% |
Nursing and Health Professions | 11 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Agricultural and Biological Sciences | 7 | 5% |
Psychology | 4 | 3% |
Other | 10 | 7% |
Unknown | 43 | 32% |