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Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances

Overview of attention for article published in BMC Genomics, December 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
peer_reviews
1 peer review site

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
21 Mendeley
citeulike
2 CiteULike
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Title
Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances
Published in
BMC Genomics, December 2011
DOI 10.1186/1471-2164-12-604
Pubmed ID
Authors

Ariel Fernández, Yun-Huei Tzeng, Sze-Bi Hsu

Abstract

Driven essentially by random genetic drift, subfunctionalization has been identified as a possible non-adaptive mechanism for the retention of duplicate genes in small-population species, where widespread deleterious mutations are likely to cause complementary loss of subfunctions across gene copies. Through subfunctionalization, duplicates become indispensable to maintain the functional requirements of the ancestral locus. Yet, gene duplication produces a dosage imbalance in the encoded proteins and thus, as investigated in this paper, subfunctionalization must be subject to the selective forces arising from the fitness bottleneck introduced by the duplication event.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 10%
Netherlands 1 5%
Canada 1 5%
Unknown 17 81%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 38%
Student > Ph. D. Student 5 24%
Professor > Associate Professor 4 19%
Student > Master 1 5%
Student > Bachelor 1 5%
Other 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 76%
Biochemistry, Genetics and Molecular Biology 3 14%
Social Sciences 1 5%
Medicine and Dentistry 1 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2015.
All research outputs
#1,918,004
of 22,708,120 outputs
Outputs from BMC Genomics
#515
of 10,624 outputs
Outputs of similar age
#14,605
of 242,597 outputs
Outputs of similar age from BMC Genomics
#10
of 301 outputs
Altmetric has tracked 22,708,120 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,624 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,597 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 301 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.