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Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ

Overview of attention for article published in Respiratory Research, November 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

twitter
6 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
62 Mendeley
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Title
Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ
Published in
Respiratory Research, November 2016
DOI 10.1186/s12931-016-0477-6
Pubmed ID
Authors

Paula N. Nonaka, Juan J. Uriarte, Noelia Campillo, Vinicius R. Oliveira, Daniel Navajas, Ramon Farré

Abstract

A current approach to obtain bioengineered lungs as a future alternative for transplantation is based on seeding stem cells on decellularized lung scaffolds. A fundamental question to be solved in this approach is how to drive stem cell differentiation onto the different lung cell phenotypes. Whereas the use of soluble factors as agents to modulate the fate of stem cells was established from an early stage of the research with this type of cells, it took longer to recognize that the physical microenvironment locally sensed by stem cells (e.g. substrate stiffness, 3D architecture, cyclic stretch, shear stress, air-liquid interface, oxygenation gradient) also contributes to their differentiation. The potential role played by physical stimuli would be particularly relevant in lung bioengineering since cells within the organ are physiologically subjected to two main stimuli required to facilitate efficient gas exchange: air ventilation and blood perfusion across the organ. The present review focuses on describing how the cell mechanical microenvironment can modulate stem cell differentiation and how these stimuli could be incorporated into lung bioreactors for optimizing organ bioengineering.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 16%
Researcher 10 16%
Student > Master 9 15%
Student > Bachelor 7 11%
Student > Doctoral Student 2 3%
Other 9 15%
Unknown 15 24%
Readers by discipline Count As %
Engineering 10 16%
Medicine and Dentistry 9 15%
Agricultural and Biological Sciences 9 15%
Materials Science 4 6%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 10 16%
Unknown 17 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2020.
All research outputs
#5,089,619
of 17,429,432 outputs
Outputs from Respiratory Research
#637
of 2,201 outputs
Outputs of similar age
#123,709
of 398,542 outputs
Outputs of similar age from Respiratory Research
#41
of 125 outputs
Altmetric has tracked 17,429,432 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,201 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 398,542 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.