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Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma

Overview of attention for article published in BMC Cancer, November 2016
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28 Mendeley
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Title
Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma
Published in
BMC Cancer, November 2016
DOI 10.1186/s12885-016-2928-3
Pubmed ID
Authors

Jian Zhang, Jianwei Ren, Jiamin Wei, Charing C. N. Chong, Dongjie Yang, Yulong He, George G. Chen, Paul B. S. Lai

Abstract

The role of estrogen receptor alpha (ERa), estrogen receptor beta (ERb) and ERa36 signaling in hepatocellular carcinoma (HCC) is not fully addressed. In this study, three cohorts were included: (i) primary HCC patients (N = 76, cohort P), (ii) colorectal liver metastasis (mCRC) (N = 32, cohort S), and (iii) HCC from The Cancer Genome Atlas (TCGA) (N = 121). The levels of ERa36 and wtER36 were measured and their correlation with clinicopathologic features was determined. WtERa was downregulated and that ERa36 was upregulated in tumor tissues in both cohort P and TCGA data set. ERa36 was downregulated in tumor tissues in cohort S. In cohort P, wtERa was differentially expressed in gender (P < 0.000), age (P = 0.004), tumor number (P = 0.043), tumor size (P = 0.002), intrahepatic recurrence (P = 0.054). ERa36 was unequally expressed in different non-tumor liver status (P = 0.040). WtERa was negatively associated with overall survival (OS) and disease free survival (DFS) in cohort P. Compared with non-tumor tissues, the expression of ERa36 was increased in primary HCC but decreased in secondary HCC, showing opposite expression patterns of ERa36 between primary HCC and secondary HCC. Primary HCC is associated with the decreased WtERa but increased ERa36. The expression pattern of ERa36 is different between primary HCC and secondary HCC, as the former with the increased ERa36 but the latter with the decreased ERa36. Therefore, the expression of ERa36 may be used to differentiate the primary HCC and the secondary one.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Student > Master 5 18%
Student > Bachelor 3 11%
Student > Ph. D. Student 3 11%
Other 2 7%
Other 4 14%
Unknown 5 18%
Readers by discipline Count As %
Medicine and Dentistry 10 36%
Biochemistry, Genetics and Molecular Biology 7 25%
Agricultural and Biological Sciences 4 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 5 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2016.
All research outputs
#6,626,624
of 8,701,275 outputs
Outputs from BMC Cancer
#2,294
of 3,585 outputs
Outputs of similar age
#206,323
of 298,947 outputs
Outputs of similar age from BMC Cancer
#62
of 110 outputs
Altmetric has tracked 8,701,275 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,585 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.