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Ancient origin of somatic and visceral neurons

Overview of attention for article published in BMC Biology, April 2013
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Title
Ancient origin of somatic and visceral neurons
Published in
BMC Biology, April 2013
DOI 10.1186/1741-7007-11-53
Pubmed ID
Authors

Marc Nomaksteinsky, Stefan Kassabov, Zoubida Chettouh, Henri-Corto Stoeklé, Laure Bonnaud, Gilles Fortin, Eric R Kandel, Jean-François Brunet

Abstract

A key to understanding the evolution of the nervous system on a large phylogenetic scale is the identification of homologous neuronal types. Here, we focus this search on the sensory and motor neurons of bilaterians, exploiting their well-defined molecular signatures in vertebrates. Sensorimotor circuits in vertebrates are of two types: somatic (that sense the environment and respond by shaping bodily motions) and visceral (that sense the interior milieu and respond by regulating vital functions). These circuits differ by a small set of largely dedicated transcriptional determinants: Brn3 is expressed in many somatic sensory neurons, first and second order (among which mechanoreceptors are uniquely marked by the Brn3+/Islet1+/Drgx+ signature), somatic motoneurons uniquely co-express Lhx3/4 and Mnx1, while the vast majority of neurons, sensory and motor, involved in respiration, blood circulation or digestion are molecularly defined by their expression and dependence on the pan-visceral determinant Phox2b.

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Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 3%
United Kingdom 1 <1%
Norway 1 <1%
United States 1 <1%
Unknown 95 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 21%
Researcher 21 21%
Student > Bachelor 12 12%
Student > Master 6 6%
Professor 6 6%
Other 20 20%
Unknown 15 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 40%
Biochemistry, Genetics and Molecular Biology 13 13%
Neuroscience 10 10%
Medicine and Dentistry 6 6%
Nursing and Health Professions 2 2%
Other 12 12%
Unknown 18 18%