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Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche

Overview of attention for article published in Skeletal Muscle, December 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 290)
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
25 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
50 Mendeley
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Title
Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche
Published in
Skeletal Muscle, December 2016
DOI 10.1186/s13395-016-0111-9
Pubmed ID
Authors

Ivana Dinulovic, Regula Furrer, Markus Beer, Arnaud Ferry, Bettina Cardel, Christoph Handschin

Abstract

The myogenic capacity of satellite cells (SCs), adult muscle stem cells, is influenced by aging, exercise, and other factors. In skeletal muscle, the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key regulator of oxidative metabolism and endurance training adaptation. However, a link between PGC-1α and SC behavior remains unexplored. We have now studied SC function in a PGC-1α fiber-specific gain-of-function animal model. In surprising contrast to bona fide exercise, muscle-specific PGC-1α transgenic mice have lower SC numbers. Nevertheless, SCs from these mice have a higher propensity for activation and proliferation. Intriguingly, muscle PGC-1α triggers a remodeling of the SC niche by altering the extracellular matrix composition, including the levels of fibronectin, which affects the proliferative output of SCs. Taken together, PGC-1α indirectly affects SC plasticity in skeletal muscle and thereby might contribute to improved SC activation in exercise.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Switzerland 1 2%
Unknown 48 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 20%
Student > Ph. D. Student 8 16%
Researcher 8 16%
Student > Bachelor 6 12%
Student > Doctoral Student 4 8%
Other 10 20%
Unknown 4 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 40%
Agricultural and Biological Sciences 12 24%
Medicine and Dentistry 4 8%
Neuroscience 2 4%
Sports and Recreations 2 4%
Other 5 10%
Unknown 5 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2017.
All research outputs
#712,371
of 15,776,943 outputs
Outputs from Skeletal Muscle
#9
of 290 outputs
Outputs of similar age
#24,982
of 389,520 outputs
Outputs of similar age from Skeletal Muscle
#2
of 36 outputs
Altmetric has tracked 15,776,943 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 290 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 389,520 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.