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Now on display: a gallery of group II intron structures at different stages of catalysis

Overview of attention for article published in Mobile DNA, May 2013
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Title
Now on display: a gallery of group II intron structures at different stages of catalysis
Published in
Mobile DNA, May 2013
DOI 10.1186/1759-8753-4-14
Pubmed ID
Authors

Marco Marcia, Srinivas Somarowthu, Anna Marie Pyle

Abstract

Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA and RNA. They are considered evolutionary ancestors of the spliceosome, the ribonucleoprotein complex essential for pre-mRNA processing in higher eukaryotes. Over a 20-year period, group II introns have been characterized first genetically, then biochemically, and finally by means of X-ray crystallography. To date, 17 crystal structures of a group II intron are available, representing five different stages of the splicing cycle. This review provides a framework for classifying and understanding these new structures in the context of the splicing cycle. Structural and functional implications for the spliceosome are also discussed.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
United States 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 25%
Student > Ph. D. Student 10 18%
Student > Bachelor 8 14%
Student > Master 6 11%
Professor 4 7%
Other 6 11%
Unknown 9 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 37%
Agricultural and Biological Sciences 18 32%
Chemistry 4 7%
Materials Science 1 2%
Engineering 1 2%
Other 0 0%
Unknown 12 21%