Title |
Now on display: a gallery of group II intron structures at different stages of catalysis
|
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Published in |
Mobile DNA, May 2013
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DOI | 10.1186/1759-8753-4-14 |
Pubmed ID | |
Authors |
Marco Marcia, Srinivas Somarowthu, Anna Marie Pyle |
Abstract |
Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA and RNA. They are considered evolutionary ancestors of the spliceosome, the ribonucleoprotein complex essential for pre-mRNA processing in higher eukaryotes. Over a 20-year period, group II introns have been characterized first genetically, then biochemically, and finally by means of X-ray crystallography. To date, 17 crystal structures of a group II intron are available, representing five different stages of the splicing cycle. This review provides a framework for classifying and understanding these new structures in the context of the splicing cycle. Structural and functional implications for the spliceosome are also discussed. |
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