ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway

ApoE4 downregulates ACE2 protein expression and subsequently the dysregulation of renin–angiotensin system (RAS) may provide explanation by which ApoE4 exacerbates COVID-19 disease https://t.co/1I1d1UGLqW

https://t.co/pZH7QEHob5

> ApoE4-related diseases have > higher risk of COVID The infamous #Alzheimer’s gene …🥁… oh no > #ApoE4 significantly downregulates #ACE2 …does the *same thing*, dysregulates the *same target* as #Covid? 🤦‍♂️ 🤷‍♂️ so very unexpected —J Transl

ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway https://t.co/wc0i59FwNa https://t.co/X6HUOnAZ2J @ICMRDELHI @icmr_niv @iiscbangalore @ccmb_csir @NCBS_Bangalore https://t.co/zHJ8ar8YJC