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Understanding how we age: insights into inflammaging

Overview of attention for article published in Longevity & Healthspan, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
2 blogs
twitter
12 X users
patent
1 patent
facebook
1 Facebook page

Citations

dimensions_citation
318 Dimensions

Readers on

mendeley
433 Mendeley
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Title
Understanding how we age: insights into inflammaging
Published in
Longevity & Healthspan, May 2013
DOI 10.1186/2046-2395-2-8
Pubmed ID
Authors

Daniel Baylis, David B Bartlett, Harnish P Patel, Helen C Roberts

Abstract

Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.Inflammaging is believed to be a consequence of a remodelling of the innate and acquired immune system, resulting in chronic inflammatory cytokine production.Complex interrelated genetic, environmental and age-related factors determine an individual's vulnerability or resilience to inflammaging. These factors include polymorphisms to the promoter regions of cytokines, cytokine receptors and antagonists, age-related decreases in autophagy and increased adiposity. Anti-inflammaging describes the upregulation of the hypothalamic-pituitary axis in response to inflammaging, leading to higher levels of cortisol, which in turn may be detrimental, contributing to less successful ageing and frailty. This may be countered by the adrenal steroid dehydroepiandrosterone, which itself declines with age, leaving certain individuals more vulnerable. Inflammaging and anti-inflammaging have both been linked with a number of age-related outcomes, including chronic morbidity, functional decline and mortality. This important area of research offers unique insights into the ageing process and the potential for screening and targeted interventions.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 433 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 2 <1%
Brazil 2 <1%
United States 2 <1%
Canada 1 <1%
United Kingdom 1 <1%
Unknown 425 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 69 16%
Student > Bachelor 66 15%
Student > Ph. D. Student 58 13%
Researcher 54 12%
Other 32 7%
Other 78 18%
Unknown 76 18%
Readers by discipline Count As %
Medicine and Dentistry 92 21%
Biochemistry, Genetics and Molecular Biology 72 17%
Agricultural and Biological Sciences 59 14%
Immunology and Microbiology 29 7%
Neuroscience 17 4%
Other 74 17%
Unknown 90 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2023.
All research outputs
#1,393,207
of 24,950,117 outputs
Outputs from Longevity & Healthspan
#5
of 26 outputs
Outputs of similar age
#10,764
of 196,937 outputs
Outputs of similar age from Longevity & Healthspan
#2
of 5 outputs
Altmetric has tracked 24,950,117 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.0. This one scored the same or higher as 21 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,937 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.