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Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling

Overview of attention for article published in BMC Biology, January 2008
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Title
Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
Published in
BMC Biology, January 2008
DOI 10.1186/1741-7007-6-1
Pubmed ID
Authors

Tetsuya Okajima, BVVG Reddy, Tsukasa Matsuda, Kenneth D Irvine

Abstract

O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investigate the respective contributions of these activities to Notch signaling in Drosophila.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
China 1 2%
Brazil 1 2%
Unknown 41 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 34%
Researcher 9 20%
Professor 4 9%
Student > Master 4 9%
Student > Bachelor 3 7%
Other 5 11%
Unknown 4 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 45%
Agricultural and Biological Sciences 16 36%
Chemistry 2 5%
Business, Management and Accounting 1 2%
Immunology and Microbiology 1 2%
Other 1 2%
Unknown 3 7%