Title |
An in vitro-identified high-affinity nucleosome-positioning signal is capable of transiently positioning a nucleosome in vivo
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Published in |
Epigenetics & Chromatin, July 2010
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DOI | 10.1186/1756-8935-3-13 |
Pubmed ID | |
Authors |
Lia E Gracey, Zhi-Ying Chen, Jay M Maniar, Anton Valouev, Arend Sidow, Mark A Kay, Andrew Z Fire |
Abstract |
The physiological function of eukaryotic DNA occurs in the context of nucleosomal arrays that can expose or obscure defined segments of the genome. Certain DNA sequences are capable of strongly positioning a nucleosome in vitro, suggesting the possibility that favorable intrinsic signals might reproducibly structure chromatin segments. As high-throughput sequencing analyses of nucleosome coverage in vitro and in vivo have become possible, a vigorous debate has arisen over the degree to which intrinsic DNA:nucleosome affinities orchestrate the in vivo positions of nucleosomes, thereby controlling physical accessibility of specific sequences in DNA. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Germany | 1 | 2% |
Thailand | 1 | 2% |
Unknown | 58 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 29% |
Student > Ph. D. Student | 15 | 24% |
Student > Master | 6 | 10% |
Professor | 5 | 8% |
Student > Doctoral Student | 3 | 5% |
Other | 10 | 16% |
Unknown | 5 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 40% |
Biochemistry, Genetics and Molecular Biology | 14 | 23% |
Physics and Astronomy | 4 | 6% |
Engineering | 3 | 5% |
Medicine and Dentistry | 2 | 3% |
Other | 5 | 8% |
Unknown | 9 | 15% |