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Studies on the therapeutic effect of propolis along with standard antibacterial drug in Salmonella enterica serovar Typhimurium infected BALB/c mice

Overview of attention for article published in BMC Complementary and Alternative Medicine, November 2016
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Title
Studies on the therapeutic effect of propolis along with standard antibacterial drug in Salmonella enterica serovar Typhimurium infected BALB/c mice
Published in
BMC Complementary and Alternative Medicine, November 2016
DOI 10.1186/s12906-016-1474-5
Pubmed ID
Authors

Preeti Kalia, Neelima R. Kumar, Kusum Harjai

Abstract

Antibiotic resistance is an emerging public health problem. Centers for Disease Control and Prevention (CDC) has described antibiotic resistance as one of the world's most pressing health problems in 21(st) century. WHO rated antibiotic resistance as "one of the three greatest threats to human health". One important strategy employed to overcome this resistance is the use of combination of drugs. Many plants, natural extracts have been shown to exhibit synergistic response with standard drugs against microorganisms. The present study focused on the antibacterial potential of propolis in combination with the standard antibiotic Cefixime against the typhoid causing bacteria i.e. Salmonella. Ethanolic extract of propolis was taken for the present work. For the experiment BALB/c mice were taken as animal model and divided into ten groups. Along with normal and infected control groups, four different combinations of cefixime and propolis were used. Biochemical, hematological and histopathological indices were studied by following the standard protocols. In BALB/c mice, Salmonella causes severe biochemical, hematological and histopathological alterations by 5(th) day of infection. Ethanolic extract of propolis at a dose of 300 mg/kg body weight of mice when used alone to treat Salmonella infection in mice gave significant results by 30(th) day of treatment. Similarly, when cefixime (4 mg/kg body weight of mice) was used to treat infection in mice, significant results as compared to infected control were observed after 5(th) day. But when propolis and cefixime were used together in different concentrations in combination therapy, evident results were observed after 5 days of treatment. The levels of various liver and kidney function enzymes, blood indices and the histopathology of liver, spleen and kidney were restored to near normal after 5 days of treatment and at much lower doses as compared to the effective dose when used alone. The study confirmed that significant results were observed in three combinations of cefixime and propolis as compared to infected controls. Propolis acted synergistically with cefixime and enhanced the efficacy of antibiotic and reduced its effective dose in combined therapy.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 17%
Researcher 6 13%
Student > Ph. D. Student 6 13%
Student > Bachelor 4 9%
Other 4 9%
Other 6 13%
Unknown 13 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 21%
Pharmacology, Toxicology and Pharmaceutical Science 5 11%
Immunology and Microbiology 5 11%
Biochemistry, Genetics and Molecular Biology 4 9%
Veterinary Science and Veterinary Medicine 3 6%
Other 6 13%
Unknown 14 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2020.
All research outputs
#15,174,715
of 18,954,860 outputs
Outputs from BMC Complementary and Alternative Medicine
#2,036
of 2,997 outputs
Outputs of similar age
#291,656
of 406,040 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#163
of 259 outputs
Altmetric has tracked 18,954,860 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,997 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,040 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 259 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.