↓ Skip to main content

Cost and cost-effectiveness of tuberculosis treatment shortening: a model-based analysis

Overview of attention for article published in BMC Infectious Diseases, December 2016
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

policy
1 policy source
twitter
8 X users
facebook
1 Facebook page

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
184 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Cost and cost-effectiveness of tuberculosis treatment shortening: a model-based analysis
Published in
BMC Infectious Diseases, December 2016
DOI 10.1186/s12879-016-2064-3
Pubmed ID
Authors

G. B. Gomez, D. W. Dowdy, M. L. Bastos, A. Zwerling, S. Sweeney, N. Foster, A. Trajman, M. A. Islam, S. Kapiga, E. Sinanovic, G. M. Knight, R. G. White, W. A. Wells, F. G. Cobelens, A. Vassall

Abstract

Despite improvements in treatment success rates for tuberculosis (TB), current six-month regimen duration remains a challenge for many National TB Programmes, health systems, and patients. There is increasing investment in the development of shortened regimens with a number of candidates in phase 3 trials. We developed an individual-based decision analytic model to assess the cost-effectiveness of a hypothetical four-month regimen for first-line treatment of TB, assuming non-inferiority to current regimens of six-month duration. The model was populated using extensive, empirically-collected data to estimate the economic impact on both health systems and patients of regimen shortening for first-line TB treatment in South Africa, Brazil, Bangladesh, and Tanzania. We explicitly considered 'real world' constraints such as sub-optimal guideline adherence. From a societal perspective, a shortened regimen, priced at USD1 per day, could be a cost-saving option in South Africa, Brazil, and Tanzania, but would not be cost-effective in Bangladesh when compared to one gross domestic product (GDP) per capita. Incorporating 'real world' constraints reduces cost-effectiveness. Patient-incurred costs could be reduced in all settings. From a health service perspective, increased drug costs need to be balanced against decreased delivery costs. The new regimen would remain a cost-effective option, when compared to each countries' GDP per capita, even if new drugs cost up to USD7.5 and USD53.8 per day in South Africa and Brazil; this threshold was above USD1 in Tanzania and under USD1 in Bangladesh. Reducing the duration of first-line TB treatment has the potential for substantial economic gains from a patient perspective. The potential economic gains for health services may also be important, but will be context-specific and dependent on the appropriate pricing of any new regimen.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 184 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 38 21%
Student > Master 27 15%
Student > Ph. D. Student 18 10%
Student > Bachelor 12 7%
Student > Postgraduate 10 5%
Other 21 11%
Unknown 58 32%
Readers by discipline Count As %
Medicine and Dentistry 37 20%
Nursing and Health Professions 14 8%
Economics, Econometrics and Finance 10 5%
Social Sciences 9 5%
Business, Management and Accounting 6 3%
Other 39 21%
Unknown 69 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2021.
All research outputs
#3,946,126
of 24,241,559 outputs
Outputs from BMC Infectious Diseases
#1,274
of 8,112 outputs
Outputs of similar age
#73,269
of 424,423 outputs
Outputs of similar age from BMC Infectious Diseases
#49
of 220 outputs
Altmetric has tracked 24,241,559 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,112 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,423 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 220 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.