Title |
Seroprevalence of Streptococcal Inhibitor of Complement (SIC) suggests association of streptococcal infection with chronic kidney disease
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Published in |
BMC Nephrology, May 2013
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DOI | 10.1186/1471-2369-14-101 |
Pubmed ID | |
Authors |
Mohan Ganesh Karmarkar, Gouri Pandharinath Hule, Niwrutti Khandu Hase, Preeti Rajeev Mehta, Scott Robert Walter, Kadaba Srinivasa Sriprakash |
Abstract |
Group A streptococcus (GAS) is an etiological agent for the immune mediated sequela post streptococcal glomerulonephritis (PSGN). In some populations PSGN is recognized as a risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). It was found that a significantly greater proportion of subjects with past history of PSGN than without the history exhibited seroreactions to streptococcal antigens called streptococcal inhibitor of complement (SIC) and to distantly related SIC (DRS). These antigens are expressed by major PSGN-associated GAS types. We therefore predicted that in populations such as India, which is endemic for streptococcal diseases and which has high prevalence of CKD and ESRD, greater proportions of CKD and ESRD patients exhibit seroreaction to SIC and DRS than healthy controls. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Sri Lanka | 1 | 9% |
Unknown | 10 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 36% |
Student > Bachelor | 2 | 18% |
Professor | 1 | 9% |
Lecturer > Senior Lecturer | 1 | 9% |
Researcher | 1 | 9% |
Other | 1 | 9% |
Unknown | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 27% |
Agricultural and Biological Sciences | 2 | 18% |
Nursing and Health Professions | 1 | 9% |
Psychology | 1 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Other | 0 | 0% |
Unknown | 3 | 27% |