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Development and progress for three decades in umu test systems

Overview of attention for article published in Genes and Environment, December 2016
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Title
Development and progress for three decades in umu test systems
Published in
Genes and Environment, December 2016
DOI 10.1186/s41021-016-0054-8
Pubmed ID
Authors

Yoshimitsu Oda

Abstract

Umu test have been widely used to predict the detection and assessment of DNA- damaging chemicals in environmental genotoxicity field for three decades. This test system is more useful with respect to simplicity, sensitivity, rapidity, and reproducibility. A review of the literature on the development of the umu test is presented in this article. The contents of this article are included a description of numerous data using the umu test. This test have been fully evaluated and used in many directions. Different genetically engineered umu systems introducing bacterial and rat or human drug metabolizing enzymes into the umu tester strains, have been successfully established and are considered as useful tools for genotoxicity assays to study the mechanisms of biotransformation in chemical carcinogenesis. Actually, we developed that two types of bacterial metabolizing enzymes and 4 types of rat and human metabolizing enzyme DNAs are expressed in these strains such as nitroreductase and O-acetyltransferase, cytochrome P450, N-acetyltransferases, sulfotransferases, and glutathione S-transferases, respectively. Due to increasing numbers of minute environmental samples and new pharmaceuticals, a high-throughput umu test system using Salmonella typhimurium TA1535/pSK1002, NM2009, and NM3009 strains provides a useful for these genotoxicity screening. I also briefly describe the first attempts to incorporate such umu tester strain into photo-genotoxicity test.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 23%
Student > Ph. D. Student 8 19%
Researcher 5 12%
Student > Master 4 9%
Student > Doctoral Student 2 5%
Other 2 5%
Unknown 12 28%
Readers by discipline Count As %
Environmental Science 12 28%
Biochemistry, Genetics and Molecular Biology 6 14%
Agricultural and Biological Sciences 4 9%
Medicine and Dentistry 2 5%
Nursing and Health Professions 1 2%
Other 6 14%
Unknown 12 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2016.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Genes and Environment
#88
of 135 outputs
Outputs of similar age
#313,394
of 416,449 outputs
Outputs of similar age from Genes and Environment
#5
of 10 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 135 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,449 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.