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A pilot randomized controlled trial of a tailored cognitive behavioural therapy based intervention for depressive symptoms in those newly diagnosed with multiple sclerosis

Overview of attention for article published in BMC Psychiatry, December 2016
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Title
A pilot randomized controlled trial of a tailored cognitive behavioural therapy based intervention for depressive symptoms in those newly diagnosed with multiple sclerosis
Published in
BMC Psychiatry, December 2016
DOI 10.1186/s12888-016-1152-7
Pubmed ID
Authors

Litza A. Kiropoulos, Trevor Kilpatrick, Alex Holmes, Jennifer Threader

Abstract

To examine the effectiveness and acceptability of an 8-week individual tailored cognitive behavioural therapy (CBT) intervention for the treatment of depressive symptoms in those newly diagnosed with multiple sclerosis. The current study presents a pilot, parallel group randomized controlled trial (RCT) with an allocation ratio of 1:1 conducted in a large research and teaching hospital in Melbourne, Australia. 30 individuals with a mean age of 36.93 years (SD = 9.63) who were newly diagnosed with multiple sclerosis (MS) (X = 24.87 months, SD = 15.61) were randomized to the CBT intervention (n = 15) or treatment as usual (TAU) (n = 15). The primary outcome was level of depressive symptoms using the Beck Depression Inventory-II (BDI-II). Secondary outcomes were level of anxiety, fatigue and pain impact, sleep quality, coping, acceptance of MS illness, MS related quality of life, social support, and resilience. Tertiary outcomes were acceptability and adherence to the intervention. Large between group treatment effects were found for level of depressive symptoms at post and at 20 weeks follow-up (d = 1.66-1.34). There were also small to large group treatment effects for level of anxiety, fatigue and pain impact, sleep quality, MS related quality of life, resilience, and social support at post and at 20 weeks follow-up (d = 0.17-1.63). There were no drop-outs and participants completed all treatment modules. All participants reported the treatment as 'very useful', and most (73.4%) reported that the intervention had addressed their problems 'completely'. These data suggest that the tailored early intervention is appropriate and clinically effective for the treatment of depressive symptoms in those newly diagnosed with MS. A larger RCT comparing the CBT intervention with an active comparative treatment with longer term follow-up and cost effectiveness analyses is warranted. The pilot trial has been retrospectively registered on 28/04/2016 with the ISRCTN registry (trial ID ISRCTN10423371).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 <1%
Brazil 1 <1%
Unknown 209 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 34 16%
Student > Bachelor 29 14%
Student > Ph. D. Student 23 11%
Researcher 19 9%
Student > Doctoral Student 12 6%
Other 31 15%
Unknown 63 30%
Readers by discipline Count As %
Psychology 58 27%
Nursing and Health Professions 25 12%
Medicine and Dentistry 20 9%
Social Sciences 9 4%
Unspecified 8 4%
Other 20 9%
Unknown 71 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2017.
All research outputs
#18,171,876
of 23,342,092 outputs
Outputs from BMC Psychiatry
#3,803
of 4,816 outputs
Outputs of similar age
#293,930
of 422,278 outputs
Outputs of similar age from BMC Psychiatry
#84
of 97 outputs
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