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X Demographics
Mendeley readers
Attention Score in Context
| Title |
LRRK2 at the interface of autophagosomes, endosomes and lysosomes
|
|---|---|
| Published in |
Molecular Neurodegeneration, December 2016
|
| DOI | 10.1186/s13024-016-0140-1 |
| Pubmed ID | |
| Authors |
Dorien A. Roosen, Mark R. Cookson |
| Abstract |
Over the past 20 years, substantial progress has been made in identifying the underlying genetics of Parkinson's disease (PD). Of the known genes, LRRK2 is a major genetic contributor to PD. However, the exact function of LRRK2 remains to be elucidated. In this review, we discuss how familial forms of PD have led us to hypothesize that alterations in endomembrane trafficking play a role in the pathobiology of PD. We will discuss the major observations that have been made to elucidate the role of LRRK2 in particular, including LRRK2 animal models and high-throughput proteomics approaches. Taken together, these studies strongly support a role of LRRK2 in vesicular dynamics. We also propose that targeting these pathways may not only be beneficial for developing therapeutics for LRRK2-driven PD, but also for other familial and sporadic cases. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 206 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Unknown | 205 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 20% |
| Researcher | 34 | 17% |
| Student > Bachelor | 29 | 14% |
| Student > Master | 28 | 14% |
| Student > Doctoral Student | 6 | 3% |
| Other | 19 | 9% |
| Unknown | 48 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 47 | 23% |
| Neuroscience | 39 | 19% |
| Agricultural and Biological Sciences | 32 | 16% |
| Medicine and Dentistry | 14 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Other | 16 | 8% |
| Unknown | 51 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2016.
All research outputs
#14,286,049
of 22,908,162 outputs
Outputs from Molecular Neurodegeneration
#684
of 852 outputs
Outputs of similar age
#227,741
of 419,655 outputs
Outputs of similar age from Molecular Neurodegeneration
#14
of 16 outputs
Altmetric has tracked 22,908,162 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 852 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.2. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,655 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.