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Delivery of gene silencing agents for breast cancer therapy

Overview of attention for article published in Breast Cancer Research, May 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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5 X users
patent
1 patent
facebook
1 Facebook page

Citations

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28 Dimensions

Readers on

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55 Mendeley
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Title
Delivery of gene silencing agents for breast cancer therapy
Published in
Breast Cancer Research, May 2013
DOI 10.1186/bcr3413
Pubmed ID
Authors

Haifa Shen, Vivek Mittal, Mauro Ferrari, Jenny Chang

Abstract

The discovery of RNA interference has opened the door for the development of a new class of cancer therapeutics. Small inhibitory RNA oligos are being designed to specifically suppress expression of proteins that are traditionally considered nondruggable, and microRNAs are being evaluated to exert broad control of gene expression for inhibition of tumor growth. Since most naked molecules are not optimized for in vivo applications, the gene silencing agents need to be packaged into delivery vehicles in order to reach the target tissues as their destinations. Thus, the selection of the right delivery vehicles serves as a crucial step in the development of cancer therapeutics. The current review summarizes the status of gene silencing agents in breast cancer and recent development of candidate cancer drugs in clinical trials. Nanotechnology-based delivery vectors for the formulation and packaging of gene silencing agents are also described.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 24%
Researcher 10 18%
Student > Bachelor 8 15%
Student > Master 7 13%
Student > Postgraduate 4 7%
Other 8 15%
Unknown 5 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 25%
Biochemistry, Genetics and Molecular Biology 11 20%
Medicine and Dentistry 6 11%
Chemistry 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 10 18%
Unknown 7 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2018.
All research outputs
#6,374,203
of 25,377,790 outputs
Outputs from Breast Cancer Research
#728
of 2,053 outputs
Outputs of similar age
#50,513
of 205,445 outputs
Outputs of similar age from Breast Cancer Research
#13
of 26 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,445 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.