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On the importance of long-term functional assessment after stroke to improve translation from bench to bedside

Overview of attention for article published in Experimental & Translational Stroke Medicine, June 2011
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Title
On the importance of long-term functional assessment after stroke to improve translation from bench to bedside
Published in
Experimental & Translational Stroke Medicine, June 2011
DOI 10.1186/2040-7378-3-6
Pubmed ID
Authors

Thomas Freret, Pascale Schumann-Bard, Michel Boulouard, Valentine Bouet

Abstract

Despite extensive research efforts in the field of cerebral ischemia, numerous disappointments came from the translational step. Even if experimental studies showed a large number of promising drugs, most of them failed to be efficient in clinical trials. Based on these reports, factors that play a significant role in causing outcome differences between animal experiments and clinical trials have been identified; and latest works in the field have tried to discard them in order to improve the scope of the results. Nevertheless, efforts must be maintained, especially for long-term functional evaluations. As observed in clinical practice, animals display a large degree of spontaneous recovery after stroke. The neurological impairment, assessed by basic items, typically disappears during the firsts week following stroke in rodents. On the contrary, more demanding sensorimotor and cognitive tasks underline other deficits, which are usually long-lasting. Unfortunately, studies addressing such behavioral impairments are less abundant. Because the characterization of long-term functional recovery is critical for evaluating the efficacy of potential therapeutic agents in experimental strokes, behavioral tests that proved sensitive enough to detect long-term deficits are reported here. And since the ultimate goal of any stroke therapy is the restoration of normal function, an objective appraisal of the behavioral deficits should be done.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Latvia 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 25%
Student > Master 8 22%
Researcher 8 22%
Other 3 8%
Lecturer > Senior Lecturer 2 6%
Other 3 8%
Unknown 3 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 28%
Neuroscience 8 22%
Medicine and Dentistry 5 14%
Psychology 3 8%
Biochemistry, Genetics and Molecular Biology 3 8%
Other 1 3%
Unknown 6 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2013.
All research outputs
#15,271,180
of 22,709,015 outputs
Outputs from Experimental & Translational Stroke Medicine
#26
of 41 outputs
Outputs of similar age
#83,310
of 114,326 outputs
Outputs of similar age from Experimental & Translational Stroke Medicine
#2
of 3 outputs
Altmetric has tracked 22,709,015 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 41 research outputs from this source. They receive a mean Attention Score of 3.6. This one scored the same or higher as 15 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,326 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.