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The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation

Overview of attention for article published in Mobile DNA, December 2016
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  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Average Attention Score compared to outputs of the same age and source

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3 tweeters

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19 Mendeley
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Title
The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation
Published in
Mobile DNA, December 2016
DOI 10.1186/s13100-016-0081-9
Pubmed ID
Authors

Felix Broecker, Roger Horton, Jochen Heinrich, Alexandra Franz, Michal-Ruth Schweiger, Hans Lehrach, Karin Moelling

Abstract

Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, experimental evidence for an impact of these regulatory transcripts on the cellular phenotype has been lacking. We characterized the previously little described HERV-K(HML-10) endogenous retrovirus family on a genome-wide scale. HML-10 invaded the ancestral genome of Old World monkeys about 35 Million years ago and is enriched within introns of human genes when compared to other HERV families. We show that long terminal repeats (LTRs) of HML-10 exhibit variable promoter activity in human cancer cell lines. One identified HML-10 LTR-primed RNA was in opposite orientation to the pro-apoptotic Death-associated protein 3 (DAP3). In HeLa cells, experimental inactivation of HML-10 LTR-primed transcripts induced DAP3 expression levels, which led to apoptosis. Its enrichment within introns suggests that HML-10 may have been evolutionary co-opted for gene regulation more than other HERV families. We demonstrated such a regulatory activity for an HML-10 RNA that suppressed DAP3-mediated apoptosis in HeLa cells. Since HML-10 RNA appears to be upregulated in various tumor cell lines and primary tumor samples, it may contribute to evasion of apoptosis in malignant cells. However, the overall weak expression of HML-10 transcripts described here raises the question whether our result described for HeLa represent a rare event in cancer. A possible function in other cells or tissues requires further investigation.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 26%
Student > Bachelor 4 21%
Researcher 4 21%
Student > Master 3 16%
Professor > Associate Professor 1 5%
Other 1 5%
Unknown 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 37%
Biochemistry, Genetics and Molecular Biology 5 26%
Immunology and Microbiology 1 5%
Medicine and Dentistry 1 5%
Neuroscience 1 5%
Other 1 5%
Unknown 3 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2016.
All research outputs
#4,101,277
of 8,787,207 outputs
Outputs from Mobile DNA
#88
of 137 outputs
Outputs of similar age
#135,152
of 301,772 outputs
Outputs of similar age from Mobile DNA
#4
of 6 outputs
Altmetric has tracked 8,787,207 research outputs across all sources so far. This one has received more attention than most of these and is in the 52nd percentile.
So far Altmetric has tracked 137 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,772 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.