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Oxidative stress and inflammation in retained placenta: a pilot study of protein and gene expression of GPX1 and NFκB

Overview of attention for article published in BMC Pregnancy and Childbirth, December 2016
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Title
Oxidative stress and inflammation in retained placenta: a pilot study of protein and gene expression of GPX1 and NFκB
Published in
BMC Pregnancy and Childbirth, December 2016
DOI 10.1186/s12884-016-1135-1
Pubmed ID
Authors

Margit Endler, Sissel Saltvedt, Mohamed Eweida, Helena Åkerud

Abstract

Retained placenta is associated with severe postpartum hemorrhage. Its etiology is unknown and its biochemistry has not been studied. We aimed to assess whether levels of the antioxidative enzyme Glutathione Peroxidase 1 (GPX1) and the transcription factor Nuclear Factor κβ (NFκβ), as markers of oxidative stress and inflammation, were affected in retained placentas compared to spontaneously released placentas from otherwise normal full term pregnancies. In a pilot study we assessed concentrations of GPX1 by ELISA and gene (mRNA) expression of GPX1, NFκβ and its inhibitor Iκβα, by quantitative real-time-PCR in periumbilical and peripheral samples from retained (n = 29) and non-retained (n = 31) placental tissue. Median periumbilical GPX1 concentrations were 13.32 ng/ml in retained placentas and 17.96 ng/ml in non-retained placentas (p = 0.22), peripheral concentrations were 13.27 ng/ml and 19.09 ng/ml (p = 0.08). Retained placental tissue was more likely to have a low GPX1 protein concentration (OR 3.82, p = 0.02 for periumbilical and OR 3.95, p = 0.02 for peripheral samples). Median periumbilical GPX1 gene expressions were 1.13 for retained placentas and 0.88 for non-retained placentas (p = 0.08), peripheral expression was 1.32 and 1.18 (p = 0.46). Gene expressions of NFκβ and Iκβα were not significantly different between retained and non-retained placental tissue. Women with retained placenta were more likely to have a low level of GPX1 protein concentration in placental tissue compared to women without retained placenta and retained placental tissue showed a tendency of lower median concentrations of GPX1 protein expression. This may indicate decreased antioxidative capacity as a component in this disorder but requires a larger sample to corroborate results.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 11%
Student > Master 2 7%
Student > Postgraduate 2 7%
Researcher 2 7%
Lecturer 1 4%
Other 4 14%
Unknown 14 50%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 14%
Medicine and Dentistry 4 14%
Veterinary Science and Veterinary Medicine 2 7%
Nursing and Health Professions 1 4%
Unspecified 1 4%
Other 2 7%
Unknown 14 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2016.
All research outputs
#18,487,595
of 22,908,162 outputs
Outputs from BMC Pregnancy and Childbirth
#3,485
of 4,213 outputs
Outputs of similar age
#307,961
of 419,596 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#72
of 81 outputs
Altmetric has tracked 22,908,162 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,213 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,596 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.