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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The prion hypothesis in Parkinson's disease: Braak to the future
|
|---|---|
| Published in |
Acta Neuropathologica Communications, May 2013
|
| DOI | 10.1186/2051-5960-1-2 |
| Pubmed ID | |
| Authors |
Naomi P Visanji, Patricia L Brooks, Lili-Naz Hazrati, Anthony E Lang |
| Abstract |
Parkinson's disease (PD) is a progressive neurodegenerative disorder typified by the presence of intraneuronal inclusions containing aggregated alpha synuclein (αsyn). The progression of parkinsonian pathology and clinical phenotype has been broadly demonstrated to follow a specific pattern, most notably described by Braak and colleagues. In more recent times it has been hypothesized that αsyn itself may be a critical factor in mediating transmission of disease pathology from one brain area to another. Here we investigate the growing body of evidence demonstrating the ability of αsyn to spread transcellularly and induce pathological aggregation affecting neurons by permissive templating and provide a critical analysis of some irregularities in the hypothesis that the progression of PD pathology may be mediated by such a prion-like process. Finally we discuss some key questions that remain unanswered which are vital to determining the potential contribution of a prion-like process to the pathogenesis of PD. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 33% |
| United States | 4 | 27% |
| Unknown | 6 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 93% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 578 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| United Kingdom | 3 | <1% |
| Australia | 2 | <1% |
| France | 1 | <1% |
| Israel | 1 | <1% |
| Spain | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 565 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 113 | 20% |
| Student > Ph. D. Student | 96 | 17% |
| Student > Master | 78 | 13% |
| Researcher | 69 | 12% |
| Student > Doctoral Student | 38 | 7% |
| Other | 78 | 13% |
| Unknown | 106 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 120 | 21% |
| Agricultural and Biological Sciences | 98 | 17% |
| Medicine and Dentistry | 97 | 17% |
| Biochemistry, Genetics and Molecular Biology | 77 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 2% |
| Other | 47 | 8% |
| Unknown | 126 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2024.
All research outputs
#2,110,332
of 25,663,438 outputs
Outputs from Acta Neuropathologica Communications
#257
of 1,590 outputs
Outputs of similar age
#17,217
of 206,064 outputs
Outputs of similar age from Acta Neuropathologica Communications
#2
of 25 outputs
Altmetric has tracked 25,663,438 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,590 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,064 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.