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Peripheral nervous system insulin resistance in ob/ob mice

Overview of attention for article published in Acta Neuropathologica Communications, May 2013
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Title
Peripheral nervous system insulin resistance in ob/ob mice
Published in
Acta Neuropathologica Communications, May 2013
DOI 10.1186/2051-5960-1-15
Pubmed ID
Authors

Caleb W Grote, Anna L Groover, Janelle M Ryals, Paige C Geiger, Eva L Feldman, Douglas E Wright

Abstract

A reduction in peripheral nervous system (PNS) insulin signaling is a proposed mechanism that may contribute to sensory neuron dysfunction and diabetic neuropathy. Neuronal insulin resistance is associated with several neurological disorders and recent evidence has indicated that dorsal root ganglion (DRG) neurons in primary culture display altered insulin signaling, yet in vivo results are lacking. Here, experiments were performed to test the hypothesis that the PNS of insulin-resistant mice displays altered insulin signal transduction in vivo. For these studies, nondiabetic control and type 2 diabetic ob/ob mice were challenged with an intrathecal injection of insulin or insulin-like growth factor 1 (IGF-1) and downstream signaling was evaluated in the DRG and sciatic nerve using Western blot analysis.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 17%
Student > Bachelor 8 15%
Student > Ph. D. Student 8 15%
Student > Postgraduate 6 11%
Student > Doctoral Student 4 8%
Other 9 17%
Unknown 9 17%
Readers by discipline Count As %
Medicine and Dentistry 12 23%
Neuroscience 9 17%
Biochemistry, Genetics and Molecular Biology 7 13%
Agricultural and Biological Sciences 5 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 6 11%
Unknown 12 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2013.
All research outputs
#18,338,946
of 22,710,079 outputs
Outputs from Acta Neuropathologica Communications
#1,223
of 1,364 outputs
Outputs of similar age
#145,430
of 193,511 outputs
Outputs of similar age from Acta Neuropathologica Communications
#17
of 25 outputs
Altmetric has tracked 22,710,079 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,364 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,511 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.