Title |
DnaA and the timing of chromosome replication in Es-cherichia coli as a function of growth rate
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Published in |
BMC Systems Biology, December 2011
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DOI | 10.1186/1752-0509-5-201 |
Pubmed ID | |
Authors |
Matthew AA Grant, Chiara Saggioro, Ulisse Ferrari, Bruno Bassetti, Bianca Sclavi, Marco Cosentino Lagomarsino |
Abstract |
In Escherichia coli, overlapping rounds of DNA replication allow the bacteria to double in faster times than the time required to copy the genome. The precise timing of initiation of DNA replication is determined by a regulatory circuit that depends on the binding of a critical number of ATP-bound DnaA proteins at the origin of replication, resulting in the melting of the DNA and the assembly of the replication complex. The synthesis of DnaA in the cell is controlled by a growth-rate dependent, negatively autoregulated gene found near the origin of replication. Both the regulatory and initiation activity of DnaA depend on its nucleotide bound state and its availability. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Netherlands | 1 | 1% |
Unknown | 70 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 29% |
Researcher | 13 | 18% |
Student > Master | 11 | 15% |
Professor | 5 | 7% |
Professor > Associate Professor | 4 | 6% |
Other | 6 | 8% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 27 | 38% |
Biochemistry, Genetics and Molecular Biology | 19 | 26% |
Physics and Astronomy | 8 | 11% |
Environmental Science | 1 | 1% |
Mathematics | 1 | 1% |
Other | 4 | 6% |
Unknown | 12 | 17% |