Title |
Accumulation profiles of PrPScin hemal nodes of naturally and experimentally scrapie-infected sheep
|
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Published in |
BMC Veterinary Research, April 2013
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DOI | 10.1186/1746-6148-9-82 |
Pubmed ID | |
Authors |
Rohana P Dassanayake, Thomas C Truscott, M Özgür Özyiğit, Dongyue Zhuang, David A Schneider, Katherine I O’Rourke |
Abstract |
In classical scrapie, the disease-associated abnormal isoform (PrP(Sc)) of normal prion protein accumulates principally in the nervous system and lymphoid tissues of small ruminants. Lymph nodes traffic leukocytes via lymphatic and blood vasculatures but hemal nodes lack lymphatic vessels and thus traffic leukocytes only via the blood. Although PrP(Sc) accumulation profiles are well-characterized in ovine lymphoid tissues, there is limited information on such profiles in hemal nodes. Therefore, the objective of this study was to compare the follicular accumulation of PrP(Sc) within hemal nodes and lymph nodes by prion epitope mapping and western blot studies. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 12 | 100% |
Demographic breakdown
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Researcher | 4 | 33% |
Professor | 2 | 17% |
Student > Ph. D. Student | 2 | 17% |
Other | 1 | 8% |
Professor > Associate Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 1 | 8% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 3 | 25% |
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Immunology and Microbiology | 2 | 17% |
Medicine and Dentistry | 1 | 8% |
Other | 0 | 0% |
Unknown | 1 | 8% |