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Performance of Syphilis Sentinel Surveillance in the context of endemic Treponematoses: experience from Ghana

Overview of attention for article published in BMC Infectious Diseases, December 2016
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Title
Performance of Syphilis Sentinel Surveillance in the context of endemic Treponematoses: experience from Ghana
Published in
BMC Infectious Diseases, December 2016
DOI 10.1186/s12879-016-2085-y
Pubmed ID
Authors

Edward Tieru Dassah, Yaw Adu-Sarkodie, Philippe Mayaud

Abstract

Use of treponemal tests to screen for syphilis (caused by Treponema pallidum pallidum) poses challenges with infection status classification, especially in settings where other treponemal infections are endemic. This study aimed to determine the validity of the syphilis surveillance testing strategy implemented since 2004 using two treponemal tests, and estimate the seroprevalence of active syphilis infection in Ghana where yaws (caused by Treponema pallidum pertenue) is endemic. We retested sera from the 2007 HIV sentinel survey (HSS) using a traditional algorithm, quantitative rapid plasma reagin test followed by qualitative Treponema pallidum haemagglutination assay. The adjusted seroprevalence of active syphilis was calculated by applying the proportions of active syphilis within identified categories of HSS samples during the retesting, to the entire population of HSS samples. The 95% confidence intervals (CIs) were calculated for each proportion, and the t-test was used to assess differences in proportions. Of 2,214 samples that were retested, 203 (9.2%) had active syphilis infection, 21 (0.9%) were biological false reactions, 640 (28.9%) were past or treated syphilis infections, and 1,350 (61%) were uninfected. The current syphilis testing strategy overestimated the seroprevalence of active syphilis infection by a third (HSS versus traditional algorithm: 6.0% (95% CI: 5.6-6.3) vs. 4.5% (95% CI: 4.2-4.8); p < 0.001), and had low positive predictive value (16.8%) for detecting active syphilis infection. More than half (51.9%) of HSS syphilis positive cases were actually past/treated treponemal infections, possibly previous exposure to yaws. There is an urgent need to review the current syphilis sentinel surveillance testing strategy in Ghana in the context of concurrent endemic treponematoses, to better inform policy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 18%
Student > Master 6 18%
Student > Postgraduate 3 9%
Student > Ph. D. Student 3 9%
Student > Bachelor 2 6%
Other 5 15%
Unknown 9 26%
Readers by discipline Count As %
Medicine and Dentistry 11 32%
Nursing and Health Professions 6 18%
Social Sciences 3 9%
Immunology and Microbiology 1 3%
Mathematics 1 3%
Other 1 3%
Unknown 11 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2016.
All research outputs
#7,621,872
of 8,787,207 outputs
Outputs from BMC Infectious Diseases
#3,475
of 3,878 outputs
Outputs of similar age
#244,204
of 299,663 outputs
Outputs of similar age from BMC Infectious Diseases
#139
of 188 outputs
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