Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells

https://t.co/Nq9PJvwiK2 "The increased expression of these ER stress-related proteins thus confirmed that ER stress was induced by the combination of panobinostat and bortezomib."

https://t.co/Nq9PJvwiK2 "ERp44 forms mixed disulfides with Ero1-Lα and may be involved in the control of oxidative protein folding."

https://t.co/Nq9PJvwiK2 "Ero1-Lα regulates oxidative protein folding by selectively oxidizing protein disulfide isomerase, one of the key players in the control of disulfide bond formation."

https://t.co/Nq9PJvwiK2 "HSP70 is a molecular chaperone localized in the cytoplasm but associated with the regulation of the UPR by forming a stable protein complex with the cytosolic domain of inositol-requiring enzyme 1α."