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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children
|
|---|---|
| Published in |
Journal of Neuroinflammation, November 2010
|
| DOI | 10.1186/1742-2094-7-80 |
| Pubmed ID | |
| Authors |
Bodi Zhang, Asimenia Angelidou, Konstantinos-Dionysios Alysandratos, Magdalini Vasiadi, Konstantinos Francis, Shahrzad Asadi, Athanasios Theoharides, Kyriaki Sideri, Lefteris Lykouras, Dimitrios Kalogeromitros, Theoharis C Theoharides |
| Abstract |
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by difficulties in communication, cognitive and learning deficits, as well as stereotypic behaviors. For the majority of cases there are no reliable biomarkers or distinct pathogenesis. However, increasing evidence indicates ASD may be associated with some immune dysregulation, and may have a neuroimmune component. We recently showed that the peptide neurotensin (NT) is increased in autistic children. We now show that NT induces release of extracellular mitochondrial DNA (mtDNA) that could act as "autoimmune" trigger. We further show that serum from young autistic patients contains mtDNA (n = 20; cytochrome B, p = 0.0002 and 7S, p = 0.006), and anti-mitochondrial antibody Type 2 (n = 14; p = 0.001) as compared to normally developing, unrelated controls (n = 12). Extracellular blood mtDNA and other components may characterize an autistic endophenotype and may contribute to its pathogenesis by activating autoimmune responses. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Puerto Rico | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Chile | 1 | 1% |
| India | 1 | 1% |
| Italy | 1 | 1% |
| Unknown | 90 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 23% |
| Other | 11 | 11% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 7 | 7% |
| Other | 29 | 30% |
| Unknown | 7 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 25% |
| Medicine and Dentistry | 21 | 22% |
| Biochemistry, Genetics and Molecular Biology | 15 | 16% |
| Psychology | 6 | 6% |
| Neuroscience | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 11 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2018.
All research outputs
#2,595,023
of 23,164,913 outputs
Outputs from Journal of Neuroinflammation
#369
of 2,673 outputs
Outputs of similar age
#15,717
of 181,592 outputs
Outputs of similar age from Journal of Neuroinflammation
#6
of 36 outputs
Altmetric has tracked 23,164,913 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,673 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,592 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.