Title |
Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression
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Published in |
Epigenetics & Chromatin, February 2013
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DOI | 10.1186/1756-8935-6-3 |
Pubmed ID | |
Authors |
Adrienne Grzenda, Gwen Lomberk, Phyllis Svingen, Angela Mathison, Ezequiel Calvo, Juan Iovanna, Yuning Xiong, William Faubion, Raul Urrutia |
Abstract |
Histone methyltransferase enhancer of zeste homologue 2 (EZH2) forms an obligate repressive complex with suppressor of zeste 12 and embryonic ectoderm development, which is thought, along with EZH1, to be primarily responsible for mediating Polycomb-dependent gene silencing. Polycomb-mediated repression influences gene expression across the entire gamut of biological processes, including development, differentiation and cellular proliferation. Deregulation of EZH2 expression is implicated in numerous complex human diseases. To date, most EZH2-mediated function has been primarily ascribed to a single protein product of the EZH2 locus. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Brazil | 1 | 1% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 22 | 24% |
Student > Ph. D. Student | 21 | 23% |
Student > Doctoral Student | 10 | 11% |
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Student > Master | 8 | 9% |
Other | 11 | 12% |
Unknown | 10 | 11% |
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Environmental Science | 2 | 2% |
Other | 7 | 8% |
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