Title |
A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model
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Published in |
BMC Medicine, May 2013
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DOI | 10.1186/1741-7015-11-134 |
Pubmed ID | |
Authors |
Carina A Bäuerlein, Simone S Riedel, Jeanette Baker, Christian Brede, Ana-Laura Jordán Garrote, Martin Chopra, Miriam Ritz, Georg F Beilhack, Stephan Schulz, Robert Zeiser, Paul G Schlegel, Hermann Einsele, Robert S Negrin, Andreas Beilhack |
Abstract |
Acute graft-versus-host disease (aGVHD) poses a major limitation for broader therapeutic application of allogeneic hematopoietic cell transplantation (allo-HCT). Early diagnosis of aGVHD remains difficult and is based on clinical symptoms and histopathological evaluation of tissue biopsies. Thus, current aGVHD diagnosis is limited to patients with established disease manifestation. Therefore, for improved disease prevention it is important to develop predictive assays to identify patients at risk of developing aGVHD. Here we address whether insights into the timing of the aGVHD initiation and effector phases could allow for the detection of migrating alloreactive T cells before clinical aGVHD onset to permit for efficient therapeutic intervention. |
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United States | 2 | 67% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Italy | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
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Other | 6 | 23% |
Researcher | 3 | 12% |
Student > Master | 2 | 8% |
Student > Postgraduate | 1 | 4% |
Other | 0 | 0% |
Unknown | 5 | 19% |
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Chemistry | 2 | 8% |
Other | 2 | 8% |
Unknown | 6 | 23% |