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A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model

Overview of attention for article published in BMC Medicine, May 2013
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3 X users

Citations

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Title
A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model
Published in
BMC Medicine, May 2013
DOI 10.1186/1741-7015-11-134
Pubmed ID
Authors

Carina A Bäuerlein, Simone S Riedel, Jeanette Baker, Christian Brede, Ana-Laura Jordán Garrote, Martin Chopra, Miriam Ritz, Georg F Beilhack, Stephan Schulz, Robert Zeiser, Paul G Schlegel, Hermann Einsele, Robert S Negrin, Andreas Beilhack

Abstract

Acute graft-versus-host disease (aGVHD) poses a major limitation for broader therapeutic application of allogeneic hematopoietic cell transplantation (allo-HCT). Early diagnosis of aGVHD remains difficult and is based on clinical symptoms and histopathological evaluation of tissue biopsies. Thus, current aGVHD diagnosis is limited to patients with established disease manifestation. Therefore, for improved disease prevention it is important to develop predictive assays to identify patients at risk of developing aGVHD. Here we address whether insights into the timing of the aGVHD initiation and effector phases could allow for the detection of migrating alloreactive T cells before clinical aGVHD onset to permit for efficient therapeutic intervention.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 35%
Other 6 23%
Researcher 3 12%
Student > Master 2 8%
Student > Postgraduate 1 4%
Other 0 0%
Unknown 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 4 15%
Medicine and Dentistry 4 15%
Immunology and Microbiology 3 12%
Chemistry 2 8%
Other 2 8%
Unknown 6 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2014.
All research outputs
#15,272,611
of 22,711,242 outputs
Outputs from BMC Medicine
#3,032
of 3,406 outputs
Outputs of similar age
#120,632
of 195,531 outputs
Outputs of similar age from BMC Medicine
#57
of 58 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,406 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.5. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,531 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.