Title |
Manganese Neurotoxicity: a Focus on Glutamate Transporters
|
---|---|
Published in |
Annals of Occupational and Environmental Medicine, May 2013
|
DOI | 10.1186/2052-4374-25-4 |
Pubmed ID | |
Authors |
Pratap Karki, Eunsook Lee, Michael Aschner |
Abstract |
Manganese (Mn) is an essential element that is required in trace amount for normal growth, development as well maintenance of proper function and regulation of numerous cellular and biochemical reactions. Yet, excessive Mn brain accumulation upon chronic exposure to occupational or environmental sources of this metal may lead to a neurodegenerative disorder known as manganism, which shares similar symptoms with idiopathic Parkinson's disease (PD). In recent years, Mn exposure has gained public health interest for two primary reasons: continuous increased usage of Mn in various industries, and experimental findings on its toxicity, linking it to a number of neurological disorders. Since the first report on manganism nearly two centuries ago, there have been substantial advances in the understanding of mechanisms associated with Mn-induced neurotoxicity. This review will briefly highlight various aspects of Mn neurotoxicity with a focus on the role of astrocytic glutamate transporters in triggering its pathophysiology. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 53 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 15% |
Other | 7 | 13% |
Student > Master | 7 | 13% |
Student > Bachelor | 6 | 11% |
Professor > Associate Professor | 5 | 9% |
Other | 11 | 20% |
Unknown | 10 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 19% |
Biochemistry, Genetics and Molecular Biology | 9 | 17% |
Medicine and Dentistry | 7 | 13% |
Neuroscience | 7 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Other | 5 | 9% |
Unknown | 12 | 22% |