Title |
Identification and characterization of cancer stem cells in canine mammary tumors
|
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Published in |
Acta Veterinaria Scandinavica, December 2016
|
DOI | 10.1186/s13028-016-0268-6 |
Pubmed ID | |
Authors |
Agata Rybicka, Magdalena Król |
Abstract |
Cancer stem cells (CSC) represent a small subpopulation of cells in malignant tumors that possess the unique ability to self-renew, differentiate and resist chemo- and radiotherapy. These cells have been postulated to be the basis for some of the difficulties in treating cancer, and therefore, numerous approaches have been developed to specifically target and eliminate CSC in diverse types of cancer, including breast cancer. Spontaneously occurring mammary tumors in canines share clinical and molecular similarities with the human counterpart, making the dog a potentially powerful model for the study of human breast cancer and clinical trials. Studies focused on canine mammary CSC might therefore enhance our understanding of the biology and possible treatment of the disease in both dogs and humans. In this review, we discuss various approaches currently in use to isolate and characterize canine mammary CSC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 73 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 16% |
Student > Master | 11 | 15% |
Student > Bachelor | 9 | 12% |
Student > Postgraduate | 5 | 7% |
Professor > Associate Professor | 5 | 7% |
Other | 14 | 19% |
Unknown | 17 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 25 | 34% |
Agricultural and Biological Sciences | 9 | 12% |
Medicine and Dentistry | 7 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Immunology and Microbiology | 2 | 3% |
Other | 7 | 10% |
Unknown | 19 | 26% |