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Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder

Overview of attention for article published in Molecular Autism, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
9 X users
patent
3 patents
facebook
4 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
98 Dimensions

Readers on

mendeley
148 Mendeley
citeulike
1 CiteULike
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Title
Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder
Published in
Molecular Autism, May 2013
DOI 10.1186/2040-2392-4-14
Pubmed ID
Authors

Tewarit Sarachana, Valerie W Hu

Abstract

We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). Our independent cohort studies have consistently demonstrated the reduction of RORA transcript and/or protein levels in blood-derived lymphoblasts as well as in the postmortem prefrontal cortex and cerebellum of individuals with ASD. Moreover, we have also shown that RORA has the potential to be under negative and positive regulation by androgen and estrogen, respectively, suggesting the possibility that RORA may contribute to the male bias of ASD. However, little is known about transcriptional targets of this nuclear receptor, particularly in humans.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
France 1 <1%
Unknown 143 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 22%
Researcher 25 17%
Student > Master 14 9%
Student > Doctoral Student 13 9%
Student > Bachelor 10 7%
Other 29 20%
Unknown 24 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 27%
Neuroscience 21 14%
Biochemistry, Genetics and Molecular Biology 18 12%
Medicine and Dentistry 14 9%
Psychology 12 8%
Other 14 9%
Unknown 29 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2021.
All research outputs
#1,340,257
of 25,374,917 outputs
Outputs from Molecular Autism
#128
of 719 outputs
Outputs of similar age
#10,751
of 208,194 outputs
Outputs of similar age from Molecular Autism
#7
of 17 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 719 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,194 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.