Title |
A validated spectrofluorimetric method for the determination of nifuroxazide through coumarin formation using experimental design
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Published in |
BMC Chemistry, May 2013
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DOI | 10.1186/1752-153x-7-90 |
Pubmed ID | |
Authors |
Asmaa Ahmed El-Zaher, Marianne Alphonse Mahrouse |
Abstract |
Nifuroxazide (NF) is an oral nitrofuran antibiotic, having a wide range of bactericidal activity against gram positive and gram negative enteropathogenic organisms. It is formulated either in single form, as intestinal antiseptic or in combination with drotaverine (DV) for the treatment of gastroenteritis accompanied with gastrointestinal spasm. Spectrofluorimetry is a convenient and sensitive technique for pharmaceutical quality control. The new proposed spectrofluorimetric method allows its determination either in single form or in binary mixture with DV. Furthermore, experimental conditions were optimized using the new approach: Experimental design, which has many advantages over the old one, one variable at a time (OVAT approach). |
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