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HbA1c versus oral glucose tolerance test as a method to diagnose diabetes mellitus in vascular surgery patients

Overview of attention for article published in Cardiovascular Diabetology, May 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

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8 X users
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2 patents
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1 Facebook page

Citations

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18 Dimensions

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50 Mendeley
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Title
HbA1c versus oral glucose tolerance test as a method to diagnose diabetes mellitus in vascular surgery patients
Published in
Cardiovascular Diabetology, May 2013
DOI 10.1186/1475-2840-12-79
Pubmed ID
Authors

Iren D Hjellestad, Marianne C Astor, Roy M Nilsen, Eirik Søfteland, Torbjørn Jonung

Abstract

BACKGROUND: The diagnosis of diabetes mellitus (DM) is based on either fasting plasma glucose levels or an oral glucose tolerance test (OGTT). Recently, an HbA1c value of >= 48 mmol/mol (6.5%) has been included as an additional test to diagnose DM. The purpose of this study was to validate HbA1c versus OGTT as a method to diagnose DM in vascular surgery patients. METHODS: The study population consisted of 345 patients admitted consecutively due to peripheral arterial disease. Sixty-seven patients were previously diagnosed with DM. Glucose levels of OGTT and HbA1c values were analyzed in 275 patients. The OGTT results were categorized into three groups according to the World Health Organization 1999 criteria: 1) DM defined as fasting plasma glucose (FPG) >= 7.0 mmol/L and/or two-hour value (2-h-value) >= 11.1 mmol/L; 2) intermediate hyperglycaemia, which consists of IGT (FPG < 7.0 mmol/L and a 2-h-value between 7.8 mmol/L and 11.1 mmol/L), and IFG (fasting glucose value between 6.1 mmol/L and 7.0 mmol/L with a normal 2-h-value); and 3) normal glucose metabolism defined as FPG < 6.1 mmol/L and a 2-h-value < 7.8 mmol/L. RESULTS: Of the 275 patients on whom OGTT was performed, 33 were diagnosed with DM, 90 with intermediate hyperglycaemia and 152 had normal glucose metabolism. An HbA1c value of >= 48 mmol/mol (6.5%) detected DM with a 45.5% sensitivity and a 90% specificity compared with the OGTT results. Combining the measurements of the HbA1c value with the fasting plasma glucose level (>=7.0 mmol/L) increased the sensitivity to 64%. The total prevalence of DM and intermediate hyperglycaemia was 85% based on HbA1c values and 45% based on the OGTT. CONCLUSIONS: Compared with the OGTT the HbA1c cut-off value of >= 48 mmol/mol (6.5%) had a 45.5% sensitivity to diagnose DM in patients with peripheral arterial disease. OGTT and HbA1c categorized different individuals with DM and intermediate hyperglycaemia. The total prevalence of pathologic glucose metabolism was substantially higher based on HbA1c values than based on OGTT. The high prevalence of DM and intermediate hyperglycaemia when using HbA1c in this study may reflect a high chronic glycaemic burden in patients with peripheral arterial disease. Further studies on vascular surgery patients are needed to identify which method, OGTT or HbA1c, is the better in predicting DM and future clinical development of vascular disease.Trial registration: REK vest 14109.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Sweden 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 26%
Student > Bachelor 12 24%
Student > Postgraduate 7 14%
Student > Ph. D. Student 5 10%
Other 3 6%
Other 7 14%
Unknown 3 6%
Readers by discipline Count As %
Medicine and Dentistry 33 66%
Nursing and Health Professions 8 16%
Agricultural and Biological Sciences 2 4%
Immunology and Microbiology 2 4%
Engineering 1 2%
Other 0 0%
Unknown 4 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2022.
All research outputs
#3,138,139
of 25,371,288 outputs
Outputs from Cardiovascular Diabetology
#249
of 1,653 outputs
Outputs of similar age
#26,109
of 207,658 outputs
Outputs of similar age from Cardiovascular Diabetology
#1
of 27 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,653 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,658 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.