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Procalcitonin as a biomarker in equine chronic pneumopathies

Overview of attention for article published in BMC Veterinary Research, December 2016
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Title
Procalcitonin as a biomarker in equine chronic pneumopathies
Published in
BMC Veterinary Research, December 2016
DOI 10.1186/s12917-016-0912-4
Pubmed ID
Authors

Ann Kristin Barton, Anna Pelli, Martin Rieger, Heidrun Gehlen

Abstract

Procalcitonin (PCT), a precursor protein of the hormone calcitonin, is a sensitive inflammatory marker in human medicine, which is primarily used for diagnosis of bacterial sepsis, but is also useful in diagnosis of exacerbation of asthma and COPD. In this study, PCT was evaluated as a potential biomarker for different chronic pneumopathies in the horse using an equine specific ELISA in comparison to established clinical markers and different interleukins. Sixty-four horses were classified as free of respiratory disease, recurrent airway obstruction (RAO), inflammatory airway disease (IAD) or chronic interstitial pneumopathy (CIP) using a scoring system. PCT concentrations were measured in plasma (n = 17) and in the cell-free supernatant of bronchoalveolar lavage (n = 64). PCT concentrations were correlated to interleukins IL-1ß and IL-6 in BALF, clinical findings and BALF cytology. The median PCT concentrations in plasma were increased in respiratory disease (174.46 ng/ml, n = 7) compared to controls (13.94 ng/ml, n = 10, P = 0.05) and correlated to PCT in BALF supernatant (rs = 0.48). Compared to controls (5.49 ng/ml, n = 15), median PCT concentrations in BALF supernatant correlated to the overall clinical score (rs = 0.32, P = 0.007) and were significantly increased in RAO (13.40 ng/ml, n = 21) and IAD (16.89 ng/ml, n = 16), while no differences were found for CIP (12.02 ng/ml, n = 12). No significant increases were found for IL-1 and IL-6 between controls and respiratory disease in general as well as different disease groups. Although some correlations were found between PCT in plasma, BALF supernatant and clinical scores, PCT in BALF does not seem to be a superior marker compared to established clinical markers. PCT in plasma seems to be more promising and a greater number of samples should be evaluated in further studies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 5 19%
Student > Bachelor 3 11%
Student > Postgraduate 3 11%
Student > Ph. D. Student 2 7%
Student > Master 2 7%
Other 5 19%
Unknown 7 26%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 10 37%
Medicine and Dentistry 3 11%
Agricultural and Biological Sciences 2 7%
Social Sciences 1 4%
Nursing and Health Professions 1 4%
Other 0 0%
Unknown 10 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2016.
All research outputs
#18,504,575
of 22,925,760 outputs
Outputs from BMC Veterinary Research
#1,927
of 3,057 outputs
Outputs of similar age
#308,217
of 419,507 outputs
Outputs of similar age from BMC Veterinary Research
#27
of 43 outputs
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We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.