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Attention Score in Context
| Title |
Human amniotic fluid-derived and dental pulp-derived stem cells seeded into collagen scaffold repair critical-size bone defects promoting vascularization
|
|---|---|
| Published in |
Stem Cell Research & Therapy, May 2013
|
| DOI | 10.1186/scrt203 |
| Pubmed ID | |
| Authors |
Tullia Maraldi, Massimo Riccio, Alessandra Pisciotta, Manuela Zavatti, Gianluca Carnevale, Francesca Beretti, Giovanni B La Sala, Antonella Motta, Anto De Pol |
| Abstract |
INTRODUCTION: The main aim of this study is to evaluate potential human stem cells, such as dental pulp stem cells and amniotic fluid stem cells, combined with collagen scaffold to reconstruct critical-size cranial bone defects in an animal model. METHODS: We performed two symmetric full-thickness cranial defects on each parietal region of rats and we replenished them with collagen scaffolds with or without stem cells already seeded into and addressed towards osteogenic lineage in vitro. After 4 and 8 weeks, cranial tissue samples were taken for histological and immunofluorescence analysis. RESULTS: We observed a new bone formation in all of the samples but the most relevant differences in defect correction were shown by stem cell-collagen samples 4 weeks after implant, suggesting a faster regeneration ability of the combined constructs. The presence of human cells in the newly formed bone was confirmed by confocal analysis with an antibody directed to a human mitochondrial protein. Furthermore, human cells were found to be an essential part of new vessel formation in the scaffold. CONCLUSION: These data confirmed the strong potential of bioengineered constructs of stem cell-collagen scaffold for correcting large cranial defects in an animal model and highlighting the role of stem cells in neovascularization during skeletal defect reconstruction. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | 1% |
| Colombia | 1 | 1% |
| Unknown | 98 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 25% |
| Student > Master | 13 | 13% |
| Student > Bachelor | 10 | 10% |
| Researcher | 8 | 8% |
| Student > Postgraduate | 8 | 8% |
| Other | 16 | 16% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 32% |
| Agricultural and Biological Sciences | 18 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Engineering | 6 | 6% |
| Materials Science | 4 | 4% |
| Other | 8 | 8% |
| Unknown | 25 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2014.
All research outputs
#14,170,673
of 22,711,242 outputs
Outputs from Stem Cell Research & Therapy
#1,090
of 2,410 outputs
Outputs of similar age
#109,753
of 195,531 outputs
Outputs of similar age from Stem Cell Research & Therapy
#18
of 25 outputs
Altmetric has tracked 22,711,242 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,410 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,531 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.