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Dynamic properties of independent chromatin domains measured by correlation spectroscopy in living cells

Overview of attention for article published in Epigenetics & Chromatin, December 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#27 of 575)
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

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1 news outlet
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24 X users
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

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44 Dimensions

Readers on

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65 Mendeley
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Title
Dynamic properties of independent chromatin domains measured by correlation spectroscopy in living cells
Published in
Epigenetics & Chromatin, December 2016
DOI 10.1186/s13072-016-0093-1
Pubmed ID
Authors

Malte Wachsmuth, Tobias A. Knoch, Karsten Rippe

Abstract

Genome organization into subchromosomal topologically associating domains (TADs) is linked to cell-type-specific gene expression programs. However, dynamic properties of such domains remain elusive, and it is unclear how domain plasticity modulates genomic accessibility for soluble factors. Here, we combine and compare a high-resolution topology analysis of interacting chromatin loci with fluorescence correlation spectroscopy measurements of domain dynamics in single living cells. We identify topologically and dynamically independent chromatin domains of ~1 Mb in size that are best described by a loop-cluster polymer model. Hydrodynamic relaxation times and gyration radii of domains are larger for open (161 ± 15 ms, 297 ± 9 nm) than for dense chromatin (88 ± 7 ms, 243 ± 6 nm) and increase globally upon chromatin hyperacetylation or ATP depletion. Based on the domain structure and dynamics measurements, we propose a loop-cluster model for chromatin domains. It suggests that the regulation of chromatin accessibility for soluble factors displays a significantly stronger dependence on factor concentration than search processes within a static network.

X Demographics

X Demographics

The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Lithuania 1 2%
Unknown 63 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 28%
Researcher 11 17%
Student > Bachelor 7 11%
Student > Master 4 6%
Other 3 5%
Other 8 12%
Unknown 14 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 29%
Biochemistry, Genetics and Molecular Biology 14 22%
Physics and Astronomy 8 12%
Chemical Engineering 2 3%
Medicine and Dentistry 2 3%
Other 5 8%
Unknown 15 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2017.
All research outputs
#1,482,561
of 23,577,761 outputs
Outputs from Epigenetics & Chromatin
#27
of 575 outputs
Outputs of similar age
#32,167
of 423,184 outputs
Outputs of similar age from Epigenetics & Chromatin
#1
of 13 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 575 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,184 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.