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Canine cancer immunotherapy studies: linking mouse and human

Overview of attention for article published in Journal for Immunotherapy of Cancer, December 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)

Mentioned by

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4 tweeters
facebook
1 Facebook page

Citations

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68 Dimensions

Readers on

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127 Mendeley
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Title
Canine cancer immunotherapy studies: linking mouse and human
Published in
Journal for Immunotherapy of Cancer, December 2016
DOI 10.1186/s40425-016-0200-7
Pubmed ID
Authors

Jiwon S. Park, Sita S. Withers, Jaime F. Modiano, Michael S. Kent, Mingyi Chen, Jesus I. Luna, William T. N. Culp, Ellen E. Sparger, Robert B. Rebhun, Arta M. Monjazeb, William J. Murphy, Robert J. Canter

Abstract

Despite recent major clinical breakthroughs in human cancer immunotherapy including the use of checkpoint inhibitors and engineered T cells, important challenges remain, including determining the sub-populations of patients who will respond and who will experience at times significant toxicities. Although advances in cancer immunotherapy depend on preclinical testing, the majority of in-vivo testing currently relies on genetically identical inbred mouse models which, while offering critical insights regarding efficacy and mechanism of action, also vastly underrepresent the heterogeneity and complex interplay of human immune cells and cancers. Additionally, laboratory mice uncommonly develop spontaneous tumors, are housed under specific-pathogen free conditions which markedly impacts immune development, and incompletely model key aspects of the tumor/immune microenvironment. The canine model represents a powerful tool in cancer immunotherapy research as an important link between murine models and human clinical studies. Dogs represent an attractive outbred combination of companion animals that experience spontaneous cancer development in the setting of an intact immune system. This allows for study of complex immune interactions during the course of treatment while also directly addressing long-term efficacy and toxicity of cancer immunotherapies. However, immune dissection requires access to robust and validated immune assays and reagents as well as appropriate numbers for statistical evaluation. Canine studies will need further optimization of these important mechanistic tools for this model to fulfill its promise as a model for immunotherapy. This review aims to discuss the canine model in the context of existing preclinical cancer immunotherapy models to evaluate both its advantages and limitations, as well as highlighting its growth as a powerful tool in the burgeoning field of both human and veterinary immunotherapy.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 127 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 16%
Student > Ph. D. Student 19 15%
Researcher 17 13%
Student > Bachelor 17 13%
Student > Doctoral Student 9 7%
Other 25 20%
Unknown 20 16%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 33 26%
Medicine and Dentistry 14 11%
Biochemistry, Genetics and Molecular Biology 13 10%
Agricultural and Biological Sciences 10 8%
Immunology and Microbiology 7 6%
Other 23 18%
Unknown 27 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2017.
All research outputs
#10,752,801
of 19,196,842 outputs
Outputs from Journal for Immunotherapy of Cancer
#1,398
of 2,110 outputs
Outputs of similar age
#180,810
of 405,157 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#52
of 78 outputs
Altmetric has tracked 19,196,842 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,110 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,157 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.